In the 11 patients whose baseline AQP4-IgG serostatus was positive, 9 patients became seronegative by the immunofluorescence or cell-binding assays available at the time; complement activating and cell-killing ability of patient serum was switched off in 6 of 7 patients with before and after HSCT testing. Two patients remained AQP4-IgG-seropositive (with persistent complement activating and cell-killing ability) and relapsed within 2 years of HSCT. No patient with seronegative conversion relapsed…
In order to reset the immune system to baseline function, autologous hematopoietic stem cell transplantation (HSCT) has been performed in patients with multiple sclerosis…
Patients with cancer frequently experience neuropsychiatric symptoms due to their medical illness or
its treatment. In recent decades, psychiatrists have become increasingly involved in the care of patients
with cancer. However, psychiatrists may be less familiar with hematopoietic stem cell transplantation
(HSCT), a distinct cancer treatment modality associated with multiple neuropsychiatric sequelae.
Conclusions and Relevance In this preliminary study of patients with relapsing-remitting MS, nonmyeloablative HSCT, compared with DMT…
The “Things We Do for No Reason” series reviews practices
which have become common parts of hospital care but which may provide little value to our patients.
NIH-funded study finds transplantation superior to treatment with immune-suppressing drug.
Letter to the Editor published by JAMA
Early and late endocrine disorders are among the most common complications in survivors after
hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT).
Hematopoietic stem cell transplantation (HSCT) is an aggressive therapeutic procedure that consists in
the administration of high-dose chemotherapy (conditioning regimen) sometimes associated with
radiotherapy prior to an infusion of hematopoietic stem cell precursors.
Cyclophosphamide (cy) is an alkylating agent used to treat malignancies and immune-mediated inflammatory nonmalignant processes…
HSCT Protocols for a variety of locations including A. A. Maximov aHSCT protocol for autoimmune diseases (Russia); Clínica Ruiz, The Mexican Method: aHSCT for MS patients (Mexico); Artemis Hospital aHSCT for MS patients (India); and Raffles Cancer Centre aHSCT for autoimmune diseases (Singapore); and MakatiMed aHSCT for MS patients (Philippines)
To address the psychological impact of the transplant on quality of life including physical,
psychological, social and spiritual for the patient and caregiver and to discuss the nurse’s emotional
labor of caring and compassion fatigue for such an intense vulnerable population.